Can single knockouts accurately single out gene functions?
نویسندگان
چکیده
منابع مشابه
Random Phenotypic Variation of Yeast (Saccharomyces cerevisiae) Single-Gene Knockouts Fits a Double Pareto-Lognormal Distribution
BACKGROUND Distributed robustness is thought to influence the buffering of random phenotypic variation through the scale-free topology of gene regulatory, metabolic, and protein-protein interaction networks. If this hypothesis is true, then the phenotypic response to the perturbation of particular nodes in such a network should be proportional to the number of links those nodes make with neighb...
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ژورنال
عنوان ژورنال: BMC Systems Biology
سال: 2008
ISSN: 1752-0509
DOI: 10.1186/1752-0509-2-50